Sholpan Askarova

Chronic Ultrasound (‘Emotional’) Stress in Mice Exacerbates Colitis Through GSK3β-Mediated Neuroimmune Dysregulation and Is Ameliorated by Probiotic Intervention

Background: Growing evidence supports a bidirectional relationship between ‘emotional’ (psychological) stress and intestinal inflammation. ‘Emotional stress’, a form of stress that is triggered by negative information and experiences of non-physical nature, is an established risk...

Cdc42 in Tumor Hypoxia: Molecular Mechanisms of Cellular Adaptation

Tumor hypoxia is a hallmark of solid tumors that promotes aggressiveness and resistance to therapy. Within hypoxic tumors, hypoxia-inducible factor (HIF)-dependent transcriptional programs drive metabolic reprogramming, lactate accumulation, extracellular acidosis, angiogenesis,...

Efficacy of Low Dose of Dihydroquercetin (DHQ) in Two Genetic Models of Neurodegeneration: Insights from FUS[1-359]-Tg and APPswe/PS1dE9 Paradigms

Dihydroquercetin (DHQ), a powerful antioxidant and regulator of cellular metabolism, was proposed for therapy of neurodegenerative disorders. Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS) are serious neurodegenerative disorders with oxidative stress as an overl...