Shiyan Wan

Cardiac fibroblast-derived GNL3 aggravates acute doxorubicin-induced cardiac injury via FasL-linked fibroblast–cardiomyocyte crosstalk

Doxorubicin (DOX)-induced cardiac injury remains a major clinical challenge in oncology, with limited preventive strategies beyond dexrazoxane. Although cardiomyocyte-centered mechanisms dominate current understanding, the contribution of cardiac fibroblasts (CFs) remains incompl...