Shinsuke Sakai

TFEB drives ER stress-induced apoptosis and limits cyst growth in polycystic kidney disease

Abstract Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the progressive growth of renal cysts and loss of renal function. Here, it was demonstrated that transcription factor EB (TFEB) activation in cyst-lining epithelial cells enhances their susceptibili...