Shingo Kimura

Systematic mutagenesis assay promotes comprehension of the strand-bias laws for mutations induced by oxidative DNA damage

Ionizing radiation-induced cancer is largely indistinguishable from spontaneous cancer, particularly following low-dose and low-dose-rate exposures, making the underlying mutational mechanisms difficult to define. Under such exposure conditions, radiation-generated reactive oxyge...

Piezo1 Activation by Yoda1 Inhibits Mechanosensitive ATP Release in Human Urothelial Cells and Bladder Overactivity in Rats with Bladder Outlet Obstruction

Urothelial ATP release during bladder filling modulates afferent nerve activity and detrusor contractility to regulate the micturition reflex, yet the upstream mechanosensory mechanism linking distension to ATP release remains unclear. Here we investigated the role of Piezo1 in r...