Shingo Iwami

Temporal dissection of hepatitis C virus and orthoflavivirus infections by continuous luminescence monitoring

Virus infection is a dynamic process consisting of rapidly evolving viral and host events, yet conventional endpoint assays provide only fragmented snapshots of these processes. Here, we established a unified temporal framework for dissecting virus-host interactions by integratin...

Plasticity of extrachromosomal DNA segregation during drug adaptation

Uneven segregation during mitosis is a striking feature of extrachromosomal DNA (ecDNA). Because ecDNA lacks a centromere, it is thought to segregate stochastically, generating intratumoral heterogeneity in genomic copy number. Drug treatment can readily change ecDNA copy number,...