Shimaa A. Abass

Neuroprotective effects of empagliflozin and metformin combined therapy on rotenone induced Parkinsonism in Wistar rats via PI3K and PPARγ modulation

Abstract Parkinsonism is a progressive neurodegenerative disorder characterized by dopaminergic neuronal loss and α-synuclein aggregation within the substantia nigra pars compacta (SNc). We investigated the potential neuroprotective effects of metformin and empagliflozin, individ...

Bioactive goldenseal (Hydrastis canadensis) fraction suppresses multidrug-resistant Pseudomonas aeruginosa in a rat burn wound model: oral and topical administration

Abstract Multidrug-resistant (MDR) Pseudomonas aeruginosa is a prominent pathogen implicated in burn wound infections, creating substantial therapeutic obstacles due to its antibiotic resistance and enhanced virulence mediated by quorum sensing (QS). This study explored the anti-...