Shi Wang

A case of progressive multifocal leukoencephalopathy in a cirrhotic patient

Progressive multifocal leukoencephalopathy (PML) is a rare fatal central nervous system demyelinating disease caused by John Cunningham virus (JCV). Immunodeficiency induces JCV reactivation, resulting in oligodendrocyte lysis, demyelination, and astrocytic dysfunction. We report...