Shi Huairui

Apelin overexpression remodels aged mesenchymal stem cells to generate miR-486a-5p-enriched exosomes that drive cardiac repair

Abstract Background Mesenchymal stem cell (MSC)-based therapy has shown promising cardioprotective effects in myocardial infarction (MI), yet the therapeutic utility of aged MSCs (AMSCs) is substantially compromised by replicative senescence and functional decline during in vitro...