Sheng Tong

Latexin deletion in the bone marrow niche suppresses leukemia via LIFR downregulation and immune activation

Acute myeloid leukemia (AML) is the most common adult leukemia diagnosis. Bone marrow (BM) niche significantly influences the initiation and progression of AML. However, our knowledge about the effect of leukemic niche on leukemia stem cells (LSC) and leukemogenesis is limited. I...