Shelly Vogelesang-Ganon

Masking phosphatidylserine prevents neuronal loss in two distinct Drosophila models of neurodegeneration

Neuronal loss is a hallmark of neurodegenerative diseases. Phosphatidylserine (PS), a key “eat me” signal, is exposed on stressed viable neurons, triggering their premature phagocytosis by activated glia. We investigated whether PS masking could serve as a universal strategy to p...