Shanyang He

Single-nucleus transcriptomics reveals an early-relapse-associated epithelial–myeloid–T cell niche in advanced high-grade serous ovarian cancer

Early relapse remains a major clinical challenge in advanced HGSOC, but the tumor microenvironmental features associated with relapse timing remain poorly defined. Here, we performed snRNA-seq on treatment-naive tumors from patients with advanced HGSOC, including STDFS ( n = 4) a...