Shanling Jiang

The D380 residue in MCO1 regulates neural iron homeostasis and fitness in Drosophila

Iron dyshomeostasis has been implicated in the aging and pathogenesis of numerous neurodegenerative diseases, however, the underlying mechanisms are largely unknown. Previously, we determined that Drosophila melanogaster multicopper oxidase-1 (MCO1) has dual-functional catalytic...