Shangyu Chen

Glycosaminoglycan-Based CD44-Targeted Nanoparticles for Cancer Therapy: Biological Barriers and Barrier-Informed Design Strategies

Abstract Nanoparticle (NP)-based drug delivery has been explored to improve the therapeutic index of anticancer agents by enhancing tumor accumulation and reducing systemic toxicity. Among active targeting approaches, cluster of differentiation 44 (CD44) has attracted attention b...

Free Bubble-Assisted Interfacial Assembly of Amphiphilic NIR-II Small Molecules with Enhanced Fluorescence Brightness

Abstract The second near-infrared window (NIR-II, 1000–1700 nm) holds promise for in vivo bioimaging owing to its inherent advantages such as minimized background autofluorescence, reduced light scattering, and deep tissue penetration. Donor–acceptor–donor (D–A–D)-type small mole...

Nanocarrier-mediated targeting of chemotherapy-induced DPP4 enhances T cell infiltration and improves cancer immunochemotherapy

Cancer immunotherapy has transformed cancer treatment, yet its efficacy remains limited by a “cold” tumor immune microenvironment (TIME) characterized by poor T cell infiltration. Induction of immunogenic cell death (ICD) improves T cell infiltration by promoting the release of T...