Shang Gao

Atroposelective Synthesis of Axially Chiral Diaryl Ethers via Organocatalyzed Enantioselective Desymmetric Allyl Addition

Catalytic asymmetric construction of C─O axially chiral diaryl ethers remains underdeveloped relative to C─C biaryl atropisomers, and examples that simultaneously create a stereogenic carbon center are scarce. Herein, we report a chiral phosphoric acid‐catalyzed enantioselective...

Harnessing the Silicon Effect for Copper-Catalyzed Linear- E -Selective Reductive Coupling of Ketones with Allenylsilanes

Abstract We report a copper-catalyzed reductive coupling of ketones with allenylsilanes that delivers γ-silyl homoallylic alcohols with exceptional linear E-selectivities. Mechanistic investigations indicate that the silyl substituent functions as a directing element for regiosel...