Shane Colborne

Extracellular vesicles from chemoresistant breast cancer cells reprogram macrophages toward an M2-like phenotype in an ABCC1-dependent manner

Triple-negative breast cancer is characterized by high rates of chemoresistance and poor clinical outcomes. Although ATP-binding cassette (ABC) transporters are well-established mediators of drug efflux, their role in tumor–immune communication remains poorly defined. Here, we in...