Seyed E. Hasnain

In silico assessment of natural compounds against mycobacterium tuberculosis Rv1509 protein

Abstract Tuberculosis (TB) remains a leading cause of mortality globally, driven by the infectious pathogen, Mycobacterium tuberculosis (M.tb) . A novel DNA methyltransferase (DNA MTase), encoded by the Rv1509 gene and involved in TB pathogenesis, has been identified as a promisi...

A rationally designed PE/PPE-based multi-epitope vaccine candidate engaging TLR4 to induce balanced humoral and cellular immunity against Mycobacterium tuberculosis

TB is a serious health challenge globally, with more than 10 million new cases every year and rising MDR and XDR variants diminishing the efficacy of existing chemotherapeutics. Although BCG vaccination confers protection in children, its limited ability to prevent adult pulmonar...