Serge Gueroussov

Suppressing phosphatidylserine externalization overcomes cancer immune evasion and enhances immunotherapy

Abstract Immune checkpoint blockade (ICB) has transformed cancer therapy, yet many tumors remain refractory to treatment due to diverse immune evasion mechanisms. To uncover novel drivers of ICB resistance, we performed an in vivo CRISPR-Cas9 screen in mice with increasing levels...