Author
Sébastien Wälchli
Recent research
- Health & MedicineOpen access
Combining TAG ‐ 72CAR with anti‐ MUC16CAR improves the potency of ovarian cancer treatment
Ovarian cancer (OC) is typically associated with poor prognosis and high mortality. Chimeric antigen receptor (CAR) T‐cell therapy offers a promising strategy, yet its application in solid tumours remains constrained by limited efficacy and on‐target/off‐tumour toxicities. We pre...
- Health & MedicineOpen access
Tisa-cel and axi-cel CAR structure influences the development of resistance to CD19-CAR-T therapy
CD19-CAR-T cells are a major therapy for relapsed/refractory B-cell malignancies, yet ~50% of patients relapse after infusion. Clinical data suggest that tisa-cel treatment is associated with higher rates of CD19 mutation than axi-cel, though direct comparisons have been lacking....
- Biology
Abstract The use of natural killer (NK) cells for the treatment of solid tumors such as cholangiocarcinoma has been hindered by challenges related to cell production, persistence and trafficking, as well as by reduced efficacy within an immunosuppressive tumor microenvironment. A...