Sebastian Oltean

A novel combinatorial treatment for Neurofibromatosis type 1 tumours revealed through cross-species genetic analysis

Abstract Neurofibromatosis type 1 (NF1) is a multisystem genetic disorder associated with a wide range of symptoms, including the formation of tumours along nerves. These tumours can affect nerve function, leading to pain and loss of sensory or motor capacity. Drug treatments are...

Modulators of epithelial-mesenchymal transitions in prostate cancer: potential for novel therapeutics development

Abstract Research in the area of hallmarks of cancer has opened the possibility of designing novel therapeutic interventions based on modulating cancer properties. Interestingly, the epithelial-mesenchymal transition (EMT), important in both tumour growth and metastasis, has not...