Sean P. Palecek

FOSB and JUND transcription factors induce ABCB1 expression and regulate transport in human pluripotent stem cell-derived endothelial cells

The blood-brain barrier endothelium is distinguished by specialized transport functions, including high expression of the efflux transporter ABCB1 (P-glycoprotein). However, the transcriptional mechanisms that induce ABCB1 expression in human brain microvascular endothelial cells...