Sean P. Ferris

Surgical waste from stereotactic glioma biopsies contains clinically relevant tumor DNA

Stereotactic needle biopsy is an established approach for sampling gliomas in deep, midline, or eloquent brain regions, but tissue acquisition remains constrained by the need to preserve material for histopathology, molecular testing, and research. During routine specimen handlin...

Perinatal lead (Pb) exposure and alterations to amyloid beta and metabolic profiles in the brain

Abstract INTRODUCTION Developmental neurotoxicant exposures (e.g., lead [Pb]) are suspected contributors to dementia. Dementia is characterized by amyloid beta (Aβ) plaques and dysregulated metabolism. To better understand the relationship between environment and dementia risk, w...