Se Hwan Mun

Ent-7β-hydroxy-15-oxokaur-16-en-18-yl acetate suppresses RANKL-induced and LPS-enhanced osteoclastogenesis through NF-κB/MAPK signaling with involvement of the ACE–AT1R axis

Osteoporosis is a metabolic bone disorder characterized by excessive osteoclast-mediated bone resorption, which is exacerbated by inflammatory and oxidative stress-associated signaling pathways. Although anti-resorptive drugs are used to prevent excessive bone resorption, their l...

Dual Effects of β‐TrCP2 Deletion in Bone Homeostasis: Suppression of Osteoclastogenesis and Enhancement of Osteoblast Activity

OBJECTIVES: To elucidate role of beta-transducin repeat-containing protein 2 (β-TrCP2) in bone homeostasis for its potential as a therapeutic target for osteoporosis. METHODS: ) mice. Bone microarchitecture was assessed by micro-computed tomography, and osteoclast and osteoblast...