Scott Marshall

Comparison of pooled and Bayesian approaches for the analysis of paediatric pharmacokinetic data leveraging prior adult knowledge: A simulation case study for monoclonal antibodies against soluble targets

Aims Population pharmacokinetic (popPK) modelling is widely used to support paediatric dose optimization, yet consensus on appropriate modelling approaches remains limited. This study compared pooled and Bayesian popPK approaches for paediatric pharmacokinetics (PK) analysis usin...