Scott Kirkland Heysell

Rifampicin Pharmacokinetics and Clinical Outcomes in Tuberculosis Patients with Comorbidities: A Descriptive Longitudinal Analysis

BackgroundTuberculosis (TB) patients with comorbid may experience altered rifampicin pharmacokinetics (PK) particularly in sub-Saharan Africa, affecting treatment response. necessitates a use of therapeutic drug monitoring (TDM) as a tool to identify suboptimal level. We describe...

Distinct transcriptional remodeling of immune and metabolic pathways in severe undernutrition during latent tuberculosis infection does not consistently predict tuberculosis progression across independent cohorts

Background: Undernutrition increases tuberculosis (TB) risk, but whether severe undernutrition during latent TB infection (LTBI) produces blood transcriptional changes that resemble active disease or identify future TB remains unclear. Methods: We reanalyzed whole-blood RNA seque...

Prospective outcomes of adults with speciated Mycobacterium avium complex lung disease, 2021-2026

Abstract Rationale Mycobacterium avium complex lung disease (MAC-LD) is clinically heterogeneous and carries diverse outcomes. Objectives To describe predictors of clinical progression of MAC-LD in a state-wide cohort. Methods We enrolled adults with MAC-LD from across Virginia,...