Satoshi Uchida

Integrating Chemistry and Biology: Evolving Design Principles Across Therapeutic Modalities

The authors declare no conflicts of interest. Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

2-arm-PEG-OligocationsTransiently Shield theLiver Sinusoids to Mitigate Off-Target Hepatic Expression of mRNALipid Nanoparticles

ABSTRACT Ionizable lipid nanoparticles (iLNPs) are powerful platforms for mRNA-based vaccines and immunotherapies; however, their intrinsic liver tropism compromises both safety and efficacy. Off-target hepatic protein expression from delivered mRNA raises safety concerns, and he...