Satoshi Matsuzaki

Triphenylphosphonium compounds preferentially inhibit long-chain fatty acid oxidation in cardiac mitochondria

Triphenylphosphonium (TPP) is a lipophilic molecule widely used in targeting compounds into the mitochondria. Despite its wide use, TPP has known mitochondrial toxicity, the characteristics of which are not completely defined. In this study, we sought to determine if the effects...