Sarah‐Jane Leigh

Sodium butyrate rescues long-term neurodevelopmental deficits following perinatal methadone exposure

Abstract Background Prenatal opioid exposure (POE) induces long-term neurodevelopmental, behavioral and cognitive deficits for which no targeted treatments are available. The mechanisms underlying POE deficits are poorly understood, but have been linked to a range of central, per...

Maternal gut microbiota–psychotropic drug interactions and their impact on offspring neurodevelopment

Pregnancy is associated with a unique and dynamic gut microbiota profile that supports fetal growth and neurodevelopment. Psychotropic drug-gut microbiota interactions are documented in the general population, yet less well described in pregnant women. Research has independently...