Sarah Mackie

Retrotransposable element derepression distinguishes DNMT3A-mutant from TET2-mutant clonal haematopoiesis

Clonal haematopoiesis (CH) is driven by somatic mutations in haematopoietic stem cells that generate clonal populations detectable in peripheral blood and is present in 10-20% of individuals over the age of 65. Mutations in DNMT3A and TET2 are the most common drivers and have bee...

Scoping review of clinical, laboratory, histopathological and imaging predictors of relapse in adults with biopsy or temporal artery ultrasound confirmed giant cell arteritis on standard therapy with glucocorticoids alone or in combination with biologics

Abstract Objective This scoping literature review aims to summarise current evidence on clinical, laboratory, histopathological and imaging predictors of relapse in adults with biopsy or imaging confirmed giant cell arteritis. Methods A comprehensive search of OVID MEDLINE(R)ALL...