Sarah C. Heilshorn

Matrix stress relaxation drives glioblastoma cell response in viscoelastic biomaterials

The extracellular matrix (ECM) of glioblastoma (GBM) is known to modulate cell behavior, yet the specific contributions of matrix biochemical and biomechanical signaling remain poorly understood. To address this, we engineer a tunable hyaluronan-elastin-like protein (HELP) hydrog...

Tuning Viscoelasticity of Dynamic Covalent Hydrogels for Human Tissue Modeling

ABSTRACT The development of three‐dimensional (3D) in vitro tissue culture models is critical for biomedical research. Hydrogel‐based systems have become preferred scaffolds for 3D models, as they have tunable viscoelastic properties, which are well‐known to influence cell morpho...