Santosh J. Gharpure

Cascade MHAT Radical Cyclopentannulation of Skipped Enyne to Access Highly Functionalized Carbocycles

Abstract An iron-mediated metal-hydride hydrogen atom transfer (MHAT) radical cyclization cascade has been developed for the efficient construction of highly functionalized carbocyclic frameworks. This versatile [3+2] cyclopentannulation strategy starting from skipped enynes prov...

Ethylene‐Mediated Template‐Free, Enyne Metathesis Gives Macrolactone 1,3‐Dienes: Synthesis of Polvolide and Muscolide From Renewable Feedstocks

A template‐free, stereodefined strategy for the synthesis of macrocyclic 1,3‐diene lactones from renewable feedstocks derived from castor and oleic oils is reported. An endo ‐selective ring‐closing ethylene‐mediated enyne metathesis (RCEYM) proceeds with complete E ‐selectivity a...