Sander Beel

Progranulin haploinsufficiency disrupts cathepsin D function, resulting in lysosomal abnormalities and elevated TDP-43 levels in the mouse brain

Introduction Frontotemporal dementia (FTD) is a leading cause of early-onset neurodegeneration, frequently linked to mutations in the GRN gene, which encodes the protein progranulin (PGRN). PGRN is known to play a crucial role in lysosomal function, and its deficiency contributes...