Sandeep Mallya

In silico evaluation of deleterious nsSNPs in SOD1 and TARDBP genes associated with amyotrophic lateral sclerosis

Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder involving mutations in the SOD1 and TARDBP genes that significantly influence its development. Nonsynonymous SNPs in these genes can disrupt protein stability, folding, and regulatory functio...