Sammy Navarre

Widening the therapeutic window: How tumor irradiation harnesses dendritic cells to locally amplify CAR T cells in solid tumor

Much effort has been devoted to making chimeric antigen receptor (CAR) T cell therapy as effective in solid tumors as it has become in B cell malignancies. Although clinical trials have demonstrated that doses up to 5 × 108 CAR T cells are generally safe, these doses rarely produ...