Sameer Rohatgi

The Valve as Boundary: Rheumatic Mitral Valve Disease as a Stasis-Acidosis-Proteinopathy Cascade Under the Brain's Defensive Decree

Background: Rheumatic heart disease remains a leading cause of valvular morbidity and mortality worldwide. The prevailing model attributes chronic rheumatic mitral valve disease to molecular mimicry—cross-reactive antibodies against Group A streptococcal antigens that target valv...

The Valve as Boundary: Rheumatic Mitral Valve Disease as a Stasis-Acidosis-Proteinopathy Cascade Under the Brain's Defensive Decree

Background: Rheumatic heart disease remains a leading cause of valvular morbidity and mortality worldwide. The prevailing model attributes chronic rheumatic mitral valve disease to molecular mimicry—cross-reactive antibodies against Group A streptococcal antigens that target valv...