Sagnika Ghosh

Leveraging Iodomethylboronic Ester Reactivity to Access Late-Stage Dehydroalanine and Dehydrovaline onto Peptides in Water

Abstract We report a mild, chemoselective late-stage conversion of cysteine and penicillamine residues into dehydroalanine (Dha) and dehydrovaline (ΔVal), respectively, in peptides via rapid bis-alkylation with the commercially available iodomethylboronic acid pinacol ester (IMBp...