sachin raj

VCF Validation Through Structural, Reference, and Genotype Checks: A Layered Approach to Variant Call Format Quality Control

The Variant Call Format (VCF) is the de facto standard for reporting genomic variants, but its permissive specification and the length of the sequencing-to-variant-calling pipeline leave room for malformed, internally inconsistent, or reference-discordant files to propagate into...

VCF Validation Through Structural, Reference, and Genotype Checks: A Layered Approach to Variant Call Format Quality Control

The Variant Call Format (VCF) is the de facto standard for reporting genomic variants, but its permissive specification and the length of the sequencing-to-variant-calling pipeline leave room for malformed, internally inconsistent, or reference-discordant files to propagate into...