Sabrina Petralla

Inflammatory stimulation remodels microglial extracellular vesicle miRNA cargo and selectively modulates recipient microglial responses

Abstract Neuroinflammation is a hallmark of neurodegenerative diseases and contributes to progressive neuronal dysfunction. Microglia, the resident immune cells of the Central Nervous System, orchestrate inflammatory responses and can transmit activation signals through extracell...

Altered Membrane Protein Abundance in the Cerebral Cortex of the JNPL3 Mouse Model of Tauopathy

Abstract Developing effective therapeutic approaches for tau-associated neurodegenerative diseases, including frontotemporal dementia and Alzheimer’s disease, remains extremely challenging due to their complex pathogeneses. Membrane proteins constitute a large proportion of curre...