Sabine Spiegl-Kreinecker

DNA methylation of silencer-annotated regions at the MGMT locus in the context of promoter and enhancer methylation in glioblastoma and melanoma brain metastases

Abstract Background MGMT promoter methylation is a well-established biomarker in glioblastoma, its relevance in melanoma brain metastases remains controversial. Recent studies indicate that methylation of MGMT enhancers contributes to MGMT regulation, whereas the role of silencer...