S K Lee

Spatially fractionated radiotherapy with PD-L1 blockade achieves superior antitumor efficacy and safety in a preclinical model of peritoneal metastasis

Abstract Peritoneal metastasis from gastrointestinal cancers has poor outcomes, and whole-abdominal radiotherapy (RT) is limited by toxicity to radiosensitive organs. Spatially fractionated radiotherapy (SFRT) delivers heterogeneous doses, potentially sparing normal tissue while...