Ryo Nagai

Development of a polyclonal antibody-based sandwich ELISpot assay for interleukin-4/13B1 in rainbow trout Oncorhynchus mykiss

Abstract In mammals, interleukin-4 (IL-4) and IL-13 are important Th2 cytokines that enhance antibody production by B cells and proliferation of Th2 cells. Salmonid fish have three homologs to both of these cytokines as a result of four rounds of whole genome duplication events,...