Ruxandra I. Dima

FlexENN: A Graph Neural Network for Binding Energy Prediction of Globular and Intrinsically Disordered Proteins

Abstract Intrinsically disordered proteins (IDPs) drive a large fraction of cellular signaling, transcription, and assembly through interfaces that often lack a defined geometry, making the prediction of their binding energies challenging for methods developed primarily for folde...

Distinct tubulin C-terminal tails control the efficiency of a microtubule severing machine

Microtubule severing enzymes of the AAA+ family are essential regulators of cytoskeletal remodeling, extracting subunits from microtubules through Adenosine triphosphate (ATP)-driven conformational changes. Among them, katanin assembles into hexameric structures and binds the neg...