Rumiko Izumi

B-cell infiltration in inclusion body myositis: association with inflammasome-related signaling and enhanced myotoxicity

Inclusion body myositis (IBM) is a degenerative, intractable, inflammatory myopathy with an immune pathomechanism. CD8+ T cell-mediated myocytotoxicity is considered a pivotal inflammatory pathogenic mechanism in IBM; however, there have been limited pathological investigations i...