Ruizhe Huang

Deep learning integration of single-cell and spatial transcriptomics reveals a neutrophil-associated mesenchymal niche and a candidate translocon dependency in lung adenocarcinoma

In lung adenocarcinoma, epithelial–mesenchymal transition drives treatment resistance and metastasis but has been dissected mainly through SPP1 ⁺ macrophages, leaving neutrophils under-resolved; we asked whether integrating consensus non-negative matrix factorization, variational...