Rui Shen

Generation and characterization of a CEACAM5 x CDH17 x CD3 tri-specific T-Cell engager for colorectal cancer therapy

Abstract Background CEACAM5 and CDH17 are highly co-expressed in certain solid tumors including colorectal cancer (CRC). Current single-target based immunotherapies, such as antibody-drug conjugates (ADC) and T cell engagers (TCE), have shown promising efficacy in clinical trials...