Rui Pereira

The challenges of direct Claisen–Schmidt condensation in the synthesis of polyhydroxylated bischalcones: experimental results supported by DFT calculations

The synthesis of chalcones commonly relies on the Claisen–Schmidt condensation, an attractive reaction owing to its operational simplicity and favorable atom economy. However, its application to acetophenones bearing multiple hydroxy substituents can be problematic, often requiri...