Rui Gao

Rigid-Flexible Coupling Pore Engineering in Covalent Organic Frameworks Enables the Selective Identification of Nucleotide Analogues

Abstract Covalent organic frameworks (COFs) offer programmable pore architectures and tunable host–guest interactions, yet their rigid channels limit the selective recognition of structurally similar biomolecules─a longstanding challenge in sensor design. Inspired by enzymatic po...