Author
Ru Bo
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Recent research
- Health & Medicine
γ-Selective Deuteration of Unactivated C(sp3)–H Bonds of Aliphatic Amines via Pd Catalysis in D2O
Abstract Selective γ-deuteration of unactivated C(sp3)–H bonds in aliphatic amines is achieved using D2O as the sole deuterium source via Pd catalysis with 3-formyl-2-pyridone as a transient directing group. The reaction proceeds in aqueous medium without acidic or fluorinated co...