Rosaura Palma Orozco

Molecular Dynamics Simulations Reveal Structural Changes Associated with the ABCA1 R230C Functional Variant

The ATP-binding cassette transporter A1 (ABCA1) functional variant R230C (rs9282541) is associated with low plasma HDL-C levels, yet its atomic-scale mechanism remains unclear. We evaluated the structural and dynamic impact of R230C compared to wild-type (WT) ABCA1 using 200 ns m...