Rosana Collepardo‐Guevara

RNA Synthesis and Degradation Regulate Biomolecular Condensates through Nonequilibrium Feedback

Abstract Transcriptional condensates operate far from equilibrium, where continuous RNA synthesis and degradation dynamically reshape condensate composition. To investigate how RNA synthesis regulates condensate properties at submolecular resolution, we introduce REACT-RNA, a che...

Near-atomistic simulations reveal the molecular principles that control chromatin structure and phase separation

Abstract Understanding how chromatin’s physicochemical properties shape its emergent organization is central to deciphering genome function. To address this, we present OpenCGChromatin, a high-performance coarse-grained model that achieves near-atomistic simulations of chromatin...