Rona Karahoda

Cannabinoids modulate inflammatory tone and attenuate inflammatory responses in human placental explants

Abstract Background With increasing cannabis use during pregnancy, understanding how cannabinoids affect placental immune function is fundamental. The placenta maintains a regulated immune environment through innate immune pathways, including nuclear factor kappa B (NF-κB)–depend...

Maternal immune activation disrupts the kynurenine pathway of tryptophan metabolism in the placenta–fetal brain axis in rats

Abstract Background Maternal immune activation is a major risk factor for neurodevelopmental disorders; however, the molecular mechanisms linking gestational inflammation to fetal brain vulnerability remain incompletely defined. The tryptophan–kynurenine pathway is highly respons...